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Caution should be exercised when the following drugs are administered concomitantly with SINEMET.
Swallow SINEMETwhole or as half tabletsonly if told by your doctorwith a glass of water.
In clinical pharmacologic studiessimultaneous administration of carbidopa and levodopa produced greater urinary excretion of levodopa in proportion to the excretion of dopamine than administration of the two drugs at separate times.
All patients should be observed carefully for the development of depression with concomitant suicidal tendencies.
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there should be not problem with maxalt and sinemet, as far as is known in the medical literature.